MODELS - I am currently exploring two models of nascent RNA-mediated gene transcription regulation:
• Argonaute-linked gene network formation based on precise RNAPII pausing
• Transposable Element remnants in transcription control and evolution
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Cryptic Promoters and Epigenetic Transcription Control: Battle of the Promoters
A brief intro to RNAPII nonprocessive transcription (the norm), bidirectional initiation (may be happening more than we think), and their potential role in:
• Transcription regulation of baseline mRNA levels
• Reversible Synthesis of mRNA-specific endo-siRNA
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Endo-siRNA and Gene Adaptation:
Self-pseudogenes and Adapting to Bad Smells
There is evidence that odor mRNA-specific endo-siRNA becomes elevated during periods of scent adaptation in C elegans. Where does the increased odr-1 endo-siRNA come from?
• Promoter activation of antisense pseudogene in trans?
• Activation of antisense cryptic promoter in cis?
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RNA & Evolution
Evolution Basics
a. CHANGE IS INEVITABLE
b. Survival requires adaptation
c. How to combine stability and changeability?
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If you would like to discuss these topics or their respective presentations, please contact me at adams@plessthan.com. I am passionate about exploring these topics with peers, and I am open to filming the discussion and hosting it on this site and the Nuclear RNA Networks YouTube channel. |
